Mrs. Lesley C McFarlane

Senior Lab Technician

Address:

Immunoassay Biomarker Core Lab
School of Medicine
Ninewells Hospital

Phone Number:

+(44) 01382 383114

Email Address:

l.c.mcfarlane@dundee.ac.uk

Biography

Lesley has over 25 years of lab experience doing analysis with Cardiovascular, Respiratory, Diabetic and Aging and Health clinical trial samples. Also samples from external pharmaceutical companies and other science institutes.

Research

Lots of experience with elisa and radioimmunoassays. Measure blood, urine, saliva, sputum and lymphocyte supernatant. Trained in sputum processing.

Certificates in GCP and GCLP.

Publications

Lesley has over 35 peer reviewed papers with a selection shown below:

NAIR A, MENZIES D, HOPKINSON P, McFARLANE L, LIPWORTH BJ.  In vivo comparison of the relative systemic bioavailability of fluticasone propionate from three anti-static spacers and a metered dose inhaler.  Br J Clin Pharmacol 2009;67:191-198

NAIR A, CLEARIE K, MENZIES D, MELDRUM K, McFARLANE LLIPWORTH BJ.  A novel breath-actuated integrated vortex spacer device increases relative lung bioavailability of fluticasone/salmeterol in combination.  Pulmonary Pharmacology & Therapeutics 2009: doi:10.1016/j.pupt.2009.02.001

NAIR A, MENZIES D, BARNES M, BURNS P, McFARLANE LLIPWORTH B.  Respirable dose delivery of fluticasone propionate from a small valved holding chamber, a compact breath actuated integrated vortex device and a metered dose inhaler.  Br J Clin Pharmacol 2008:66;20-26

MENZIES D, NAIR A, HOPKINSON P, McFARLANE LLIPWORTH BJDifferential anti-inflammatory effects of large and small particlae size inhaled corticosteroids in asthma.  Allergy 2007;62:661-667

MENZIES D, NAIR A, WILLIAMSON PA, SCHEMBRI S, AL-KHAIRALLA MZH, BARNES M, FARDON TC, McFARLANE L, MAGEE GJ, LIPWORTH BJRespiratory Symptoms, Pulmonary Function, and Markers of Inflammation Amongst Bar Workers Before and After a Legislative Ban on Smoking in Public Places.  JAMA 2006;296:1742-1748

TAYAB ZR, FARDON TC, LEE DKC, HAGGART K, McFARLANE LCLIPWORTH BJ, HOCKHAUS G.  Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate.  Br J Clin Pharmacol 2007;64:698-705

LEE DKC, FARDON TC, BATES CE, HAGGART K, McFARLANE LCLIPWORTH BJAirway and systemic effects of hydrofluoralkane formulations of high dose ciclesonide and fluticasone in moderate persistent asthma. Chest 2005;127:851-860