Professor Irene Leigh OBE CBE

Professor of Cellular and Molecular Medicine

Understanding the molecular basis of non melanoma skin cancer and of genetic skin diseases

Address:

Division of Cancer Research
Jacqui Wood Cancer Centre
University of Dundee
James Arrott Drive
Ninewells Hospital And Medical School
Dundee
DD1 9SY

Phone Number:

+(44) 01382 383157

Email Address:

i.m.leigh@dundee.ac.uk

Biography

Following appointment as Consultant Dermatologist at the Royal London Hospital in 1983 Professor Leigh established the Centre for Cutaneous Research at Barts and The London School of Medicine and Dentistry, Queen Mary University of London (BLSMD) which developed into the premier research centre in skin biology and disease in UK and arguably Europe.  During this period she became Professor of Dermatology (1992), Professor of Cell and Molecular Medicine (1999), Research Dean (1997-2002), Joint Research Director (2002-5), Dean for e-learning (2005-6).  She was appointed Head of College and Vice Principal of Dundee University in November 2006 and re‑established a research laboratory in Dundee including the CR-UK Skin Tumour Laboratory.  She was President of the Association of Physicians of UK and Ireland in 2010-11 and a council member of the Academy Medical Sciences 2009-12. She organised IID2013 in Edinburgh. She returned to full time research between Dundee, with programme grants from erc and CR-UK, and Lyon in Global Health with i-pri.. She serves on multiple grant giving bodies including the erc. She honoured with an OBE for services to medicine in 2006 and a CBE in 2012..She was awarded the Archiblad Gray medal of the British Association Dermatologists in 2012. She is a Trustee of Debra UK. She is a co-PI on a Wellcome Trust Strategic award for Dermatology and Genetic Medicine with Irwin McLean (2012-17) and is the Director of the Clinical network of DGEM: BADGEM.

Research

Key research achievements

Her research has centred around all aspects of keratinocyte biology from studying basic epithelial differentiation into disease applications, particularly the molecular mechanisms of skin cancer, genetic disease and tissue engineering and she is recognised as an international leader in those fields.  Her group have made major contributions to the understanding and treatment of human disease including:

  • Identification of the absence of type VII collagen as causative in Recessive Dystrophic Epidermolysis Bullosa (RDEB) 1985 and development of LH7.2 the widely used diagnostic monoclonal antibody (MAb) for RDEB 1985
  • Development of multiple MAb to keratins, basement membrane proteins, stem cell markers and trichocyte markers for cancer diagnosis and characterisation of genetic disease (now widely used in pathological diagnosis through multiple commercial sources e.g. LP34, LL001)1983-90
  • Identification of mutations in keratins, plectin and desmosomal proteins in > 16 hereditary skin disease and development of mutation bearing keratinocyte lines 1992-2002
  • Development of skin tissue engineering for treatment of burns, ulcers, oral and genital mucosa and provision of laboratory and clinical service in London
  • Identification of connexin mutations as major cause of hereditary sensorineural deafness as well as skin disease in London (1997‑2006)
  • Identification HPV as a major co factor in non melanoma skin cancer and identification of novel mechanisms of action (ongoing)
  • Characterisation of molecular mechanisms in non-melanoma skin cancer in immunocompetent, immunosuppressed and RDEB patients including PTPRD potential targets for treatment (CRT)

Publications

2013

  • Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJ, Wilson NJ, MLean WH, Munro CS, South AP, Leigh IM, O’Toole EA, Lundstrom, Kelsell DP. Mutations in AQP5, encodinga water- channel protein cause autosomal dominant diffuse non-epidermolytic plamoplantar keratoderma. AM J Hum Genet 2013 July.
  • Kalk MJ, Ashworth T, Wnag H, Knoechel B, Mason EF, Morgan EA. Dorfman D, Pinkus G, Weigert O, Hornick JL, Chirieac LR, Hirsch M, Oh DJ, South AP, Leigh IM, Pourreyron C, Cassidy AJ, Deangelo DJ, Weinstock DM, Krop IE, Dillon D, Brock JE, Lazar AJ, Peto M, Cho RJ, Stoeck A, Haines BB, Sathayanrayanan S, Rodig S, Aster JC. PLOS  One 2013 :*:e67306
  • Matin RN, Chikh A, Chong SL, Mesher D, Graf M, Sanza P, Sentore V, Scatolini M, Moretti F, Leigh IM, Proby CM, Costanzo A, Chiorino G, Cerio R, Harwood CA, Bergamaschi D. J Exp Med 2013 210:581-603
  • Lo Nigro C, Wang H, McHugh A, Lattanzio L, Matin R, Harwood C, Syed N, Hatzimichael E, Brisoulis E, Merlano M, Evans A, Thompson A, Leigh I, Fleming C, Inman GJ, Proby CM, Crook T. J Invest Dermatol 2013 :133:1278-85
  • Harwood CA, Mesher D, McGregor JM, Mitchell L, Leedham-Green M, Raftery M, Cerio R, Leigh IM, Proby CM. Am J Transplant 2013: 13: 199-29

2012

Teaching

Throughout  her career she has been a role model and mentor, particularly for women academics and academic dermatologist  Prof Leigh is therefore frequently consulted for career advice She is involved with allocation of Clinical Training Fellowships through the MRC College and Experts, the, the Rene Touraine and Ceries Science Advisory Boards.  She is currently President of the Rene Touraine Foundation and faculty of “Mentoring young researchers” of the ESDR.

Conferences

Prof Leigh held leadership positions in the UK and Europe, by chairing investigative dermatology societies in UK (BSID, Skin Club) and sitting on the Board of the European Society Dermatological Research (ESDR) for seven years and as President in 2000/01.  She is invited to speak/chair sessions at meetings of European Academy of Dermatology and Venereology, EDF, World Congress of Dermatology as well as national societies.  She organised the major quin-quennial investigative meeting of the International Investigative Dermatology in Edinburgh 2013 and is helping organise the World Congress Cancer of the Skin in Edinburgh in Sept 2014

Special lectures 2012-13

  • Sept 20th 2012: ESDR lecture: Funding for Dermatological Research: Lessons from the UK
  • Sept 24th 2012: Skin carcinogenesis and molecular mechanisms University of Heidelberg
  • Oct 25th 2012: Exciting times in translation ESDR young leaders
  • Dec  3rd 2012 : Developing treatments for skin cancer Translational Medicine symposium Singapore
  • June 18th 2012: Skin carcinogenesis Strathclyde University
  • July 1st: Molecular mechanisms skin carcinogenesis: Harvard School Medicine Boston
  • October 4th 2013 Women in science. The changing landscape for women in medicine Koln Germany
  • October 4th  2013 From discovery to treatment: the challenges in translation Koln Germany
  • Nov 6th 2013: Barbara Gilchrest visiting professor lecture: Challenges in translation