Professor Helen Colhoun

Professor (Clinical)

Professor Helen Colhoun  University of Dundee Medical School

Address:

CPSE
Mackenzie Building
Kirsty Semple Way
Dundee

Phone Number:

+(44) 01382 383445

Email Address:

h.colhoun@dundee.ac.uk

Biography

Helen Colhoun is Professor of Public Health at the University of Dundee and Honorary Consultant in Public Health NHS Fife. She joined the University of Dundee and NHS Fife in September 2007 having previously held tenured professorial posts in epidemiology at University College London and University College Dublin. Her major research interest is the epidemiology, including genetic epidemiology, of diabetes and its complications. Her previous observational and clinical trial research has improved understanding of the pathogenesis and means to prevent vascular disease in diabetes and has changed clinical guidelines. She leads a  core team of four statisticians, three epidemiologists and a database programmer.  Her current research programme includes

  • Discovery and validation studies  for biomarkers of diabetic complications:  Professor Colhoun  leads the non-genetic biomarker workpackage (€10 million)  of the €30 million EU Innovative Medicines  SUMMIT programme.  
  • Studies that harness the power of Scottish data-linkage systems and clinical databases to study the epidemiology of diabetes complications and the safety of drugs: Professor Colhoun leads the pharmacovigilance workpackage of the   Wellcome Trust  funded  Scottish Health Informatics Programme and  contributes to the diabetes epidemiology workpackage and the  core  research programme on provisioning datasets for research.
  • Developing new clinical trials in diabetes patients: Professor Colhoun is deputy PI of the JDRF funded trial of metformin in type 1 diabetes ($3.4 million).
  • Creating then using a large bioresource to research complications of type 1 diabetes: Professor Colhoun is the PI of the CSO and DUK funded Scottish Diabetes Research Network Type 1 Bioresource.
  • Large-scale genetic epidemiology studies.  These include studies  of  genetic determinants of diabetic nephropathy in both type 1 diabetes (in the Eurodiab Family Study cohort) and type 2 diabetes (in the Wellcome Trust Type 2 Diabetes Case-Control Collection in Tayside),   and genome-wide association studies of  intermediate phenotypes relevant to cardiovascular disease in diabetes and  of statin response in the (Collaborative Atorvastatin Diabetes Study  CARDS).

She is currently Associate Editor of Diabetologia and sits on a number of grant body panels including the Wellcome Trust Birth Cohorts Committee and was previously on the Wellcome Tust Study Design Panel.  She contributes to major  academic led clinical trials in diabetes ; currently participating  in the Phase 3A Steering committee for a new PCSK9 inhibitor , the design and operations committee for a new GLP-1 analogue CVD endpoint trial and various trial  DSMB  committees. 

Research

  • Discovery and validation studies  for biomarkers of diabetic complications:  Professor Colhoun  leads the non-genetic biomarker workpackage (€10 million)  of the €30 million EU Innovative Medicines  SUMMIT programme.
  • Studies that harness the power of Scottish data-linkage systems and clinical databases to study the epidemiology of diabetes complications and the safety of drugs: Professor Colhoun leads the pharmacovigilance workpackage of the   Wellcome Trust  funded  Scottish Health Informatics Programme and  contributes to the diabetes epidemiology workpackage and the  core  research programme on provisioning datasets for research.
  • Developing new clinical trials in diabetes patients: Professor Colhoun is deputy PI of the JDRF funded trial of metformin in type 1 diabetes ($3.4 million).
  • Creating then using a large bioresource to research complications of type 1 diabetes: Professor Colhoun is the PI of the CSO and DUK funded Scottish Diabetes Research Network Type 1 Bioresource.
  • Large-scale genetic epidemiology studies.  These include studies  of  genetic determinants of diabetic nephropathy in both type 1 diabetes (in the Eurodiab Family Study cohort) and type 2 diabetes (in the Wellcome Trust Type 2 Diabetes Case-Control Collection in Tayside),   and genome-wide association studies of  intermediate phenotypes relevant to cardiovascular disease in diabetes and  of statin response in the (Collaborative Atorvastatin Diabetes Study  CARDS).

Publications

  • Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao W, de Micco DA, Preston GM, Deshmukh H, Tan K, Fuller JH.  Total Soluble and Endogenous Secretory Receptor for Advanced Glycation Endproducts as Predictive Biomarkers of Coronary Heart Disease Risk in Patients with Type 2 Diabetes:  An Analysis From the CARDS Trial.   Diabetes 2011 Jul 19 [Epub ahead of print] 
  • The GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet. 2011 Feb;43(2):117-120.
  • Waters DD, Ho JE, DeMicco DA, Breazna A, Arsenault BJ, Wun CC, Kastelein JJ, Colhoun H, Barter P. Predictors of new-onset diabetes in patients treated with atorvastatin: results from 3 large randomized clinical trials. J Am Coll Cardiol.
  • Govan L, Wu O, Briggs A, Colhoun HM, McKnight JA, Morris AD, Pearson DW,Petrie JR, Sattar N, Wild SH, Lindsay RS; on behalf of the Scottish Diabetes  Research Network Epidemiology Group. Inpatient costs for people with type 1 and  type 2 diabetes in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia. 2011 May 24. [Epub ahead of print]
  • Colhoun HM; SDRN Epidemiology Group. Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia. 2009 Sep;52(9):1755-65.
  • Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Charlton-Menys V, Demicco DA, Fuller JH; CARDS Investigators. Effects of Atorvastatin on Kidney Outcomes and Cardiovascular Disease in Patients With Diabetes: An Analysis From the Collaborative Atorvastatin Diabetes Study CARDS. Am J Kidney Dis. 2009 Jun 18.
  • RaikouM, McGuireA, ColhounHM, BetteridgeDJ, Durrington PN, HitmanGA, NeilHAW, LivingstoneSJ, Charlton-Menys V, FullerJH on behalf of the CARDS Investigators. Cost-effectiveness of primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes: results from the Collaborative Atorvastatin Diabetes Study (CARDS) Diabetologia  2007; 50(4):733-40.
  • Soedamah-Muthu SS, Fuller JH, Mulnier HE, Raleigh VS, Lawrenson RA, Colhoun HM. High Risk of Cardiovascular Disease in Patients With Type 1 Diabetes in the UK.: A cohort study using the General Practice Research Database. Diabetes Care. 2006 Apr;29(4):798-804.
  • Soedamah-Muthu SS, Fuller JH, Mulnier HE, Raleigh VS, Lawrenson RA, Colhoun HM.  All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992-1999.  Diabetologia. 2006 Apr;49(4):660-6.
  • Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V, Fuller JH; CARDS investigators.  Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004 Aug 21;364(9435):685-96. 

Teaching

Contributes to undergraduate medical education and to Clinical   academics’

Training programme

Conferences

  • 2009  Critical markers of Disease International Symposium Invited Speaker Bethesda US
  • 2010  Invited Chair and Speaker Juvenile Diabetes Research Foundation closed workshop on clinical trials in type 1 diabetes
  • 2010 Invited Speaker Juvenile Diabetes Research Foundation closed workshop on  genetics of diabetic nephropathy
  • 2011  Invited Speaker 4th International Congress on Prediabetes and the Metabolic Syndrome, Madrid, Spain