Professor Ewan Pearson

Professor of Diabetic Medicine / Head of Clinical Translational Science / Director Dundee Clinical Academic Track

Phenotypic and genetic determinants of variability in diabetes; stratification of diabetes therapies

Address:

Division of Molecular & Clinical Medicine
Level 5, Mailbox 12
Ninewells Hospital and Medical School
Dundee
DD1 9SY

Phone Number:

+(44) 01382 383387

Email Address:

E.Z.Pearson@dundee.ac.uk

Biography

Ewan Pearson is a Professor in Diabetic Medicine at the University of Dundee, UK, and is Honorary Consultant in Diabetes and Endocrinology at Ninewells Hospital and Medical School in Dundee.  He is the Director of the Dundee Clinical Academic Track and the Academy of Medical Sciences/Wellcome funded INSPIRE lead for the University.

Professor Pearson obtained his medical degree from the University of Cambridge School of Clinical Medicine, UK. He undertook a Wellcome Trust Clinical Training fellowship with Prof Andrew Hattersley at the University of Exeter Medical School, UK and completed his PhD in the physiology and treatment of monogenic diabetes. His research interests are the phenotypic and genotypic determinants of drug response, the aetiology of young-onset diabetes and the mechanisms driving progression of diabetes.  He leads the €46M IMI-DIRECT project on stratification in Type 2 diabetes and is Strand 2 lead on the £2.7M MRC funded MASTERMIND project.  He has recently been awarded a Wellcome Trust New Investigator award to investigate drug response in Type 2 diabetes.

Research

Research interests are in stratification of diabetes, phenotypic and genotypic determinants of drug response and the aetiology of young onset diabetes such as Maturity Onset Diabetes of the Young and Neonatal Diabetes.

Publications

2016

Farmer, AJ, Rodgers, LR, Lonergan, M, Shields, B, Weedon, MN, Donnelly, L, Holman, RR, Pearson, ER & Hattersley, AT 2016, 'Adherence to oral glucose-lowering therapies and associations with 1-year HbA1c: A retrospective cohort analysis in a large primary care database' Diabetes Care, vol 39, no. 2, pp. 258-263. DOI: 10.2337/dc15-1194

McCreight, LJ, Bailey, CJ & Pearson, ER 2016, 'Metformin and the gastrointestinal tract' Diabetologia, vol 59, no. 3, pp. 426-435. DOI: 10.1007/s00125-015-3844-9

Connelly, PJ, Smith, N, Chadwick, R, Exley, AR, Shneerson, JM & Pearson, ER 2016, 'Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance' Diabetic Medicine, vol 33, no. 3, pp. 371-375. DOI: 10.1111/dme.13037

Dujic, T, Causevic, A, Bego, T, Malenica, M, Velija-Asimi, Z, Pearson, ER & Semiz, S 2016, 'Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes' Diabetic Medicine, vol 33, no. 4, 13040, pp. 511-514. DOI: 10.1111/dme.13040

Dawed, AY, Zhou, K & Pearson, ER 2016, 'Pharmacogenetics in type 2 diabetes: Influence on response to oral hypoglycemic agents' Pharmacogenomics and Personalized Medicine, vol 9, pp. 17-29. DOI: 10.2147/PGPM.S84854

Jones, AG, Lonergan, M, Henley, WE, Pearson, ER, Hattersley, AT & Shields, BM 2016, 'Should studies of diabetes treatment stratification correct for baseline HbA1c?' PLoS ONE, vol 11, no. 4, e0152428. DOI: 10.1371/journal.pone.0152428

Yaghootkar, H, Lotta, LA, Tyrrell, J, Smit, RAJ, Jones, SE, Donnelly, L, Beaumont, R, Campbell, A, Tuke, MA, Hayward, C, Ruth, KS, Padmanabhan, S, Jukema, JW, Palmer, CC, Hattersley, A, Freathy, RM, Langenberg, C, Wareham, NJ, Wood, AR, Murray, A, Weedon, MN, Sattar, N, Pearson, E, Scott, RA & Frayling, TM 2016, 'Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease' Diabetes, vol 65, no. 8, pp. 2448-2460. DOI: 10.2337/db15-1671

Zhou, K, Yee, SW, Seiser, EL, van Leeuwen, N, Tavendale, R, Dujic, T, Logie, L, Sutherland, C, Palmer, CNA & Pearson, E 2016, 'Variation in the Glucose Transporter gene SLC2A2 is associated with glycaemic response to metformin' Nature Genetics.

Zhou, K, Pedersen, HK, Dawed, AY & Pearson, ER 2016, 'Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery' Nature Reviews Endocrinology, vol 12, no. 6, pp. 337-46. DOI: 10.1038/nrendo.2016.51

Pearson, ER 2016, 'Personalized medicine in diabetes: The role of 'omics' and biomarkers' Diabetic Medicine, vol 33, no. 6, pp. 712-717. DOI: 10.1111/dme.13075

Dawed, AY, Donnelly, L, Tavendale, R, Carr, F, Leese, G, Palmer, CNA, Pearson, E & Zhou, K 2016, 'CYP2C8 and SLCO1B1 variants and therapeutic response to thiazolidinediones in patients with type 2 diabetes.' Diabetes Care. DOI: 10.2337/dc15-2464

Shepherd, M, Shields, B, Hammersley, S, Hudson, M, McDonald, TJ, Colclough, K, Oram, RA, Knight, B, Hyde, C, Cox, J, Mallam, K, Moudiotis, C, Smith, R, Fraser, B, Robertson, S, Greene, S, Ellard, S, Pearson, ER, Hattersley, AT & on behalf of the UNITED Team 2016, 'Systematic population screening, using biomarkers and genetic testing, identifies 2.5% of the U.K. pediatric diabetes population with monogenic diabetes' Diabetes Care. DOI: 10.2337/dc16-0645

Singh, JSS, Fathi, A, Vickneson, K, Mordi, I, Mohan, M, Houston, JG, Pearson, ER, Struthers, AD & Lang, CC 2016, 'Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design' Cardiovascular Diabetology, vol 15, 97. DOI: 10.1186/s12933-016-0419-0

2015

Oram, RA, McDonald, TJ, Shields, BM, Hudson, MM, Shepherd, MH, Hammersley, S, Pearson, ER, Hattersley, AT & on behalf of the UNITED Team 2015, 'Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors' Diabetes Care, vol 38, no. 2, pp. 323-328. DOI: 10.2337/dc14-0871

Dujic, T, Zhou, K, Donnelly, LA, Tavendale, R, Palmer, CNA & Pearson, ER 2015, 'Association of organic cation transporter 1 with intolerance to metformin in Type 2 diabetes: a GoDARTS study' Diabetes, vol 64, no. 5, pp. 1786-1793. DOI: 10.2337/db14-1388

Yew, TW, McCreight, L, Colclough, K, Ellard, S & Pearson, ER 2015, 'tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy' Diabetic Medicine. DOI: 10.1111/dme.13024

Pearson, ER 2015, 'Dissecting the etiology of type 2 diabetes in the Pima Indian population' Diabetes, vol 64, no. 12, pp. 3993-3995. DOI: 10.2337/dbi15-0016

2014

Pearson, E 2014, 'RD Lawrence Lecture 2013: Stratified approaches to the management of diabetes' Diabetic Medicine, vol 31, no. 4, pp. 393-398. DOI: 10.1111/dme.12391

Pearson, E 2014, 'Zinc transport and diabetes risk' Nature Genetics, vol 46, no. 4, pp. 323-4. DOI: 10.1038/ng.2934

Koivula, RW, Heggie, A, Barnett, A, Cederberg, H, Hansen, TH, Koopman, AD, Ridderstråle, M, Rutters, F, Vestergaard, H, Gupta, R, Herrgård, S, Heymans, MW, Perry, MH, Rauh, S, Siloaho, M, Teare, HJA, Thorand, B, Bell, J, Brunak, S, Frost, G, Jablonka, B, Mari, A, McDonald, TJ, Dekker, JM, Hansen, T, Hattersley, A, Laakso, M, Pedersen, O, Koivisto, V, Ruetten, H, Walker, M, Pearson, E, Franks, PW & DIRECT Consortium 2014, 'Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium' Diabetologia, vol 57, no. 6, pp. 1132-1142. DOI: 10.1007/s00125-014-3216-x

Zhou, K, Donnelly, L, Yang, J, Li, M, Deshmukh, H, Van Zuydam, N, Ahlqvist, E, Spencer, CC, Groop, L, Morris, AD, Colhoun, HM, Sham, PC, McCarthy, MI, Palmer, CNA & Pearson, ER 2014, 'Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis' The Lancet: Diabetes and Endocrinology, vol 2, no. 6, pp. 481-487. DOI: 10.1016/S2213-8587(14)70050-6

2013

Zhou, K, Donnelly, LA, Morris, AD, Franks, PW, Jennison, C, Palmer, CNA & Pearson, ER 2013, 'Clinical and genetic determinants of progression of type 2 diabetes: A DIRECT Study' Diabetes Care. DOI: 10.2337/dc13-1995

Donnelly, LA, Zhou, K, Palmer, CNA, Doney, ASF, Morris, AD & Pearson, ER 2013, 'Clinical predictors of rate of progression of type 2 diabetes: an extreme case-control study' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Zhou, K & Pearson, ER 2013, 'Insights from genome-wide association studies of drug response' Annual Review of Pharmacology and Toxicology, vol 53, pp. 299-310. DOI: 10.1146/annurev-pharmtox-011112-140237

Vella, S, Donnelly, L, Lang, CC, Pearson, ER & Petrie, JR 2013, 'Is thiazolidinedione treatment an important cause of oedema?' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Connelly, PJ, Gellatly, E, Bell, L, Shepherd, M, Hattersley, AT & Pearson, E 2013, 'Measuring endogenous insulin secretion in type 1 diabetes is life changing' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Zhou, K, Bennett, A, Coleman, R, Groves, R, Holman, R, McCarthy, M, Palmer, C & Pearson, E 2013, 'Metformin pharmacogenetics and SLC2A2: genome-wide association study and 2-stage replication in GoDARTS and UKPDS' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Donnelly, LA, van Zuydam, NR, Zhou, K, Tavendale, R, Carr, F, Maitland-van der Zee, AH, Leusink, M, de Boer, A, Doevendans, PA, Asselbergs, FW, Morris, AD, Pearson, ER, Klungel, OH, Doney, ASF & Palmer, CNA 2013, 'Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment' Pharmacogenetics and Genomics, vol 23, no. 10, pp. 518-525. DOI: 10.1097/FPC.0b013e3283642fd6

't Hart, LM, Fritsche, A, Nijpels, G, van Leeuwen, N, Donnelly, LA, Dekker, JM, Alssema, M, Fadista, J, Carlotti, F, Gjesing, AP, Palmer, CNA, van Haeften, TW, Herzberg-Schäfer, SA, Simonis-Bik, AMC, Houwing-Duistermaat, JJ, Helmer, Q, Deelen, J, Guigas, B, Hansen, T, Machicao, F, Willemsen, G, Heine, RJ, Kramer, MHH, Holst, JJ, de Koning, EJP, Häring, H-U, Pedersen, O, Groop, L, de Geus, EJC, Slagboom, PE, Boomsma, DI, Eekhoff, EMW, Pearson, ER & Diamant, M 2013, 'The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway' Diabetes. DOI: 10.2337/db13-0227

Teaching

Ewan is the INSPIRE (Academy of Medical Sciences/Wellcome Trust) lead for the University and co-director of the Dundee Clinical Academic Track.  He regularly supervises student SSCs and 4th year projects, and teaches in phase 1 and phase 2 of the medical school curriculum.

PhD Supervision

Appleby, Philip

Health and Clinical Services

Second supervisor

20/03/15 → 22/03/19

Mccreight, Laura

Molecular and Clinical Medicine

Pharmacokinetics and biological mechanisms of drug outcomes in type 2 diabetes

First/primary/lead supervisor

Supervisor 100.00%

16/02/15 → 16/02/18

Dawed, Adem

Molecular and Clinical Medicine

Genetic and non-genetic determination of drug response in diabetes

First/primary/lead supervisor

Supervisor 50.00%

1/09/14 → 1/09/18

Deshmukh, Harshal

Division of Cardiovascular & Diabetes Medicine

Genetic epidemiology studies of aspects of diabetic complications

First/primary/lead supervisor

Supervisor 50.00%

3/02/10 → 2/10/14

Liu, Yiyuan

Division of Cardiovascular & Diabetes Medicine

Clinical and genetic determinants of diabetic retinopathy

Second supervisor

 Supervisor 0.00%

23/11/09 → 22/11/13

Rundle, Jana

Biomedical Research Institute

Investigation into the role of HNF-1 transcription factors and AMP-activated protein kinase in the regulation of gluconeogenic gene expression

 First/primary/lead supervisor

 Supervisor 100.00%

1/06/06 → 1/06/11

Conferences

Invited talks at international meetings

 

2015 Take Control Peaks and Valleys Meeting, Stockholm.  “Markers that predict the insulin deficient state”

2014 American Diabetes Association Scientific Sessions.  Seminar presentation. “Pharmacogenetics in Type 2 Diabetes”

2013 “Stratified approaches to the treatment of diabetes”  A*Star/FCO meeting on stratified medicine, Singapore.

2013 Chinese Diabetes Association, Fouzhou. “Stratified approaches to the treatment of diabetes”

2013 Take Control Peaks and Valleys meetings in China, Brussels and Panama

2012 Metformin Pharmacogenetics. NIDDK workshop, Washington.

2012 World Diabetes Congress, Ohio.

2012 UK-Japan workshop in personalised medicines. Foreign & Commonwealth Office/Department Business & Innovations. Tokyo, Japan

2012 Insights into the beta cell from pharmacogenomics. Royal Society, Kavli House.

2011 Pharmacogenomics of diabetes. Royal Society for Medicine, London.

2011 Pharmacogenomics of diabetes. Nature Medicine/Merck conference “Future leaders in metabolic disease”, San Francisco, US.

2011 Diabetes UK. “Genes and treatment in diabetes”

2010 EASD Stockholm “Pharmacogenetics in diabetes”

2010 American Diabetes Association Scientific Sessions, Orlando. “Pharmacogenetics in Diabetes”