Division of Cancer Research
Ninewells Hospital and Medical School
James Arrott Drive
+(44) 01382 383680
Karam received his undergraduate degree in Pharmacy from College of pharmacy/ University of Basrah-Iraq in 2005. Also, he did MSc in Pharmacology from Collage of Medicine/ University of Basrah/ Iraq in 2009. In 2011, he affiliated to College of pharmacy/ University of Basrah-Iraq to teach Pharmacology and Toxicology. Then he got a full scholarship to study PhD by Ministry of Higher Education and Scientific Research- Iraq. Consequently, he began his PhD study at University of East Anglia under supervision of Dr Vicky Sherwood in 2013. In 2014, Karam moved to Division of Cancer Research – Dundee University to continue with his research project with Dr Vicky Sherwood who has been appointed as a Discovery Fellow in Skin Cancer Biology in the Medical Research Institute at the University of Dundee.
PhD title: Development of a New Synergistic Therapy for Malignant Melanoma Treatment
Melanoma is the most fatal form of skin cancer, it has a high propensity to spread from the skin to other organs through the process of metastasis. The incidence of the disease has considerably increased over the past forty years, in spite of the dramatic developments in understanding the molecular basis of the disease and discovering of new drugs.
The vast majority of the traditional anti-melanoma drugs do not produce a satisfactory therapeutic response in melanoma patients with late stage disease. Consequently, a combination of more than one agent of chemotherapy, hormone-, radio- and immunotherapy are currently being vigorously explored to maximize the therapeutic potential of anti-melanoma drugs and minimize undesirable side effect. Nanotechnology offers the potential to systemically deliver drug combinations to patients with metastatic melanoma though the development of multi-drug loaded targeted nanocarriers.
Here we are developing a novel combinatorial approach that can be loaded into targeted anti-melanoma nanocarriers. Specifically, two traditional anti-melanoma drugs will be embedded in supraparamagnetic iron oxide nanoparticles (SPIONs) that are specifically directed to target melanoma cells.
Mahmood KS, Ahmed JH, Jawad AM. Non-steroidal anti-inflammatory drugs (NSAIDs), free radicals and reactive oxygen species (ROS): A review of literature. The Medical Journal of Basrah University 2009; 27:46-53.
Mahmood KS, Ahmed JH, Jawad AM. The in vitro effect of paracetamol and five different NSAIDs on the MDA level in un-induced and iron-induced liver homogenate of the rabbit. Journal of the Bahrain Medical Society 2011; 23(2):
University of East Anglia symposium 2014.
University of Dundee annual student symposium 2015.
93rd Scottish Skin Biology Club – University of Dundee June 2015.