Dr. Weihua Meng

Lecturer in Genetic Epidemiology

Identifying genetic variants for common disorders

Address:

Mackenzie Building
Kirsty Semple Way
Ninewells Hospital
Dundee
DD2 4BF

Phone Number:

+(44) 01382 383419

Email Address:

w.meng@dundee.ac.uk

Biography

Dr Weihua Meng is a lecturer in Genetic Epidemiology in the Division of Population Health Sciences since 2013.

He received his clinical and laboratory training from 1997 to 2005 at Zhejiang University, China. In 2008, he was awarded a PhD degree in Human Genetics after 3 years working with Prof Pascal McKeown, Prof Frank Kee and Prof Anne Hughes in the Queen’s University Belfast. With the rising of genome-wide association studies, he participated in the MYEUROPIA project led by Prof Patrick Calvas and Prof Francois Malecaze in the INSERM, France where he received further training in Genetic Statistics. In 2011, he came back to Belfast to identify genetic mutations for rare disorders using knowledge on bioinformatics of next generation sequencing.

He is currently working with Prof Blair Smith to locate genes for chronic pain using genome-wide association methods. Meanwhile, he still contributes to reveal genes for multiple eye phenotypes such as myopia and diabetic retinopathy with Prof Colin Palmer.

In 2015, He joined the DOLORisk project: Understanding risk factors and determinants for neuropathic pain (Horizon 2020) as a coPI.

In 2016, he was appointed as a leader for research-led teaching for the Division.

In 2016, he was granted permanent residentship within two hours for his unique expertise in human micro-evolution.

Research

Dr Weihua Meng’s main research interest is to identify the genetic determinants of common complex disorders, which are normally affected by both environmental and genetic factors, such as high myopia and neuropathic pain. Using neuropathic pain as an example, satisfactory relief is only achieved in less than 30% of these patients, with consequent significant detriment to the quality of life of the remaining individuals. Once his work through genome-wide association studies find that variants in certain genes are associated with this disorder, it will confirm hypothesised pathways of pain mechanisms or suggest new ones, and provide possible drug targets for pain treatment, with potential patient benefit.

At the moment, he is datamining two datasets, the Genetics of Diabetes Audit and Research Tayside (GoDARTS) and Generation Scotland (GS), to find variants that are associated with pain.

Grants:

1.            Meng W (PI). Tenovus small grant. £15,000. A genome-wide association study to identify genetic contributors for diabetic retinopathy. 2016.03.01-2017.02.28.

2.            Meng W (PI) and Smith B. Anonymous trust. £10,000. Genome-wide association study of chronic pain using data from Generation Scotland: the Scottish Family Health Study. 2014.07.01-2015.07.01.

3.            Meng W (PI), Smith B, Hocking L and Hayward C. Pfizer £84,600. Genetics of Chronic Pain:  a meta-data analysis of Generation Scotland and 23&me Genome wide association studies. 2014.11.01-2015.06.01 (50% academic contribution)

4.            Palmer C, Kennedy G, Meng W. GSK. £ 90,042. The association between lp-PLA2 and diabetic retinopathy.  2014.07-2014.12.31 (30% academic contribution)

5.            Smith B, Palmer C, Meng W and collaborators from all over European. Horizon 2020. £600,000 to Dundee. DOLORisk: Understanding risk factors and determinants for neuropathic pain. (2015.07.01-2019.06.30) (25% academic contribution)

Publications

AIW Mayne, HP Harshavardhan, LR Johnston, W Wang, A Jariwala (2017) Cruciate Retaining compared with Posterior Stabilised Nexgen total knee arthroplasty: results at 10 years in a matched cohort. Ann Royal Collage Surgeons England, 2017; 00: 1–5.

Bentley, J. A., Thakore, S., Morrison, W. & Wang, W. (2017) Emergency Department redirection to primary care: a prospective evaluation of practice. Scottish Medical Journal. 62, 1, p. 2-10 9 p.

E.V. Chalmers, G.T. McIntyre, W. Wang, T. Gillgrass, C.B. Martin, P.A. Mossey (2016) Intraoral 3D Scanning or Dental Impressions for the Assessment of Dental Arch Relationships in Cleft Care: Which is Superior? The Cleft Palate-Craniofacial Journal, 53(5):568-577.

James Bentley, Susan Henderson, Shobhan Thakore, Michael Donald, Weijie Wang (2016) Seeking Sepsis in the Emergency Department- Identifying Barriers to Delivery of the Sepsis 6. BMJ Quality Improvement Reports 2016; u206760.w3983, doi: 10.1136/bmjquality.u206760.w3983

Catherine B. Martin, Xinhui Ma, Grant T. McIntyre, Weijie Wang, Ping Lin, Elinor V. Chalmers and Peter A. Mossey (2016) The validity and reliability of an automated method of scoring dental arch relationships in unilateral cleft lip and palate using the modified Huddart–Bodenham scoring system.  European Journal of Orthodontics, 2016, 1–6, doi:10.1093/ejo/cjw031.

Badri R Mohandhas, Navnit Makaram, Tim S Drew, Weijie Wang, Graham P Arnold and Rami J Abboud (2016) Racquet String Tension Directly Affects Force Experienced at the Elbow: Implications for the Development of Lateral Epicondylitis in Tennis Players. Shoulder and Elbow, 8,184-191,DOI: 10.1177/1758573216640201.

Jan Muhammad, Sheila Gibbs, Rami Abbound, Weijie Wang, (2015) Gait pattern recognition in cerebral palsy patients using neural network modelling. Journal of Ayub Medical College Abbottabad-Pakistan. Online Jan 2016, 27(4), 754-758.

Shahoub Sherif, Syed Hasan, Graham Arnold, Rami Abboud, Weijie Wang, (2016) Analysis of hand pressure in different crutch lengths and upper-limb movements during crutched walking. International Journal of Industrial Ergonomics, 53C, 59-66.

Ghaffar, M., Raza, S., Arnold, G., Abboud, R., Weijie Wang (2015) A Lower Limb Biomechanical Model Without Using Wand-Markers for Motion Analysis During Walking and Running. Nanotechnology and Precision Engineering, 5, 383-390.

R.D. McHenry, Graham Arnold, Weijie Wang, Rami Abboud (2015). Footwear in rock climbing: Current practice. The Foot, 25, 152-158.

Mansoor Jafri, Stuart Brown, Graham Arnold, Rami Abboud, Weijie Wang (2015). Kinematical analysis of the trunk, upper limbs and fingers during minimal access surgery when using an armrest. Ergonomics, 58(11) 1866-1877.

Chetan Kabra, Raghvendra Jaiswal, Graham Arnold, Rami Abboud, Weijie Wang, (2015) Analysis of hand pressures related to wheelchair rim sizes and upper-limb movement. International Journal of Industrial Ergonomics, 47, 45-52.

Charudatta V. Shinde, Weijie Wang, Rami J Abboud, Lynda Cochrane (2014) Analysis of Foot Pressure Variation with Change in Stride Length. IOSR Journal of Dental and Medical Sciences.Vol 13, Issue 10 Ver. IV, PP 46-51.

Weijie Wang, Rami Abboud, Michal Gunther, Robin Crompton (2014) Analysis of joint force and torque for the human and non-human ape foot during bipedal walking with implications for the evolution of the foot. Journal of Anatomy, 225, 152-166.

Graeme Nicol, Graham P. Arnold, Weijie Wang, Rami J. Abboud (2014) Dynamic pressure effect on horse and horse rider during riding. Sports Engineering, 17, 143-150.

Ali K Thabet, Emanuele Trucco, Joaquim Salvi, Weijie Wang, Rami J Abboud (2014) Dynamic 3D shape of the plantar surface of the foot using coded structured light: a technical report. Journal of Ankle and Foot Research, 7:5.

Al Rashoud, A. S., Abboud, R. J., Wang, W., Wigderowitz, C. (2014) Efficacy of low-level laser therapy applied at acupuncture points in knee osteoarthritis: a randomised double-blind comparative trial. Physiotherapy, 100, 242-248.

Mansoor Jafri, Stuart Brown, Graham Arnold, Rami Abboud, Weijie Wang (2013). Energy consumption during simulated minimal access surgery with and without using an armrest. Surgical Endoscopy, 27: 971-977.

L.Z. Yapp, G.P. Arnold, S. Nasir, Weijie Wang, J.G.B. Maclean, R.J. Abboud (2012) Assessment of talipes equinovarus treated by Ponseti technique: Three-year preliminary report. The Foot, 22, 90-94.

A.K. Ramanathan, E.J. Parish, G.P. Arnold, T.S. Drew, W. Wang, R.J. Abboud (2011) The influence of shoe sole’s varying thickness on lower limb muscle activity. Foot and Ankle Surgery, 17, 218-223.

Krishna Reddy, Linda Johnston, Weijie Wang, Rami Abboud. (2011) Does the oxford knee score complement, concur or contradict the American knee society score? Journal of Arthroplasty, 26, 714-720.

   J.A. Bentley, A.K. Ramanathan, G.P. Arnold, W. Wang, R.J. Abboud. (2011) Harmful cleats of football boots: A biomechanical evaluation. Foot and Ankle Surgery, 17, 140-144.

A.K. Ramanathan, D.T. Wallace, G.P. Arnold, T.S. Drew, W. Wang, R.J. Abboud. (2011) The effect of varying footwear configurations on the peroneus longus muscle function following inversion. The Foot, 21, 31-36.

Y. Kolwadkar, S. Brown, R. Abboud, Weijie Wang. (2011) Comparison of two actuation systems for laparoscopic surgical manipulators using motion analysis. Surgical Endoscopy, 25, 964–974.

   Syam Prabhakaran Nair, Sheila Gibbs, Graham Arnold, Rami Abboud, Weijie Wang (2010). A method to calculate the centre of the ankle joint: A comparison with the Vicon® Plug-in-Gait model. Clinical Biomechanics, 25, 582-587.

   K. Ramanathan, P. Kiran, G. P. Arnold, Weijie Wang, R. J. Abboud (2010). Repeatability of the Pedar-X In-Shoe Pressure System. Foot and Ankle Surgery, 16, 70-73.

   Wang, W.., Ming D., Wan B. (2008) Method for assessing the similarity and distance between curves/trials and its applications in gait analysis. Chinese Journal of Scientific Instrument, 29, 2017-2023.

   Wang, W. (2007) Estimate of the lower-limb-specific muscle parameters during bipedal walking for humans, apes and early hominids with the implications of body evolution. Chinese Journal of Scientific Instrument, 28, 1358-1366.

   Sellers WI, Gain MM, Wang W., Crompton RH (2005). Stride length, speed and energy costs in walking of Australopithecus afarensis: using evolutionary robotics to predict the locomotion of early human ancestors. Journal of the Royal Society Interface, 2, 431-441.

   Wang W., Crompton RH (2004). Analysis of the proportions of the human and ape foot during standing with implication for the evolution of the foot. Journal of Biomechanics, 37, 1831-1836.

   Wang W., Crompton RH, Carey TS, Li Y, Gunther MM, Savage R, Sellers WI (2004). Comparison of inverse-dynamics musculoskeletal models of AL 288-1 Australopithecus afarensis and KNM-WT 15000 Homo ergaster to modern humans, with implications for the evolution of bipedalism. Journal of Human Evolution, 47, 453-478.

   Wang W., Crompton RH (2004). The role of load-carrying in the evolution of modern body proportions. Journal of Anatomy 204, 417-430.

   Thorpe SKS, Crompton RH, Wang W. (2004). Stresses Exerted in the Hindlimb Muscles of Common Chimpanzees (Pan troglodytes) during Bipedal Locomotion. Folia Primatologica, 75: 253-265.

   Sellers WI, Dennis LA, Wang W., Crompton RH (2004). Evaluating alternative gait strategies using evolutionary robotics. Journal of Anatomy 204, 343-351.

   Wang W., Crompton RH (2003). Size and power required for motion with implication for the evolution of early hominids. Journal of Biomechanics 36, 1237-1246.

   Wang W., Crompton RH, Li Y, Gunther MM (2003). Energy transformation during erect and ‘bent-hip, bent-knee’ walking by humans with implications for the evolution of bipedalism. Journal of Human Evolution 44, 563-579. Reviewed by New Scientist Vol. 178, pp. 24 on 31 May 2003.

   Wang W., Crompton RH, Li Y, Gunther MM (2003). Optimal ratio of the upper and lower limbs in hand-carrying under the assumption of frequency coordination. Journal of Biomechanics 36, 249-252.

   Crompton RH, Thorpe S, Wang W., Li Y, Payne R, Savage R, Carey T, Aerts P, Van Elsacker L, Hofstetter A, Gunther M, Richardson J (2003). The biomechanical evolution of erect bipedality. Courier Forschungsinstitut Senckenberg 243, 135-146.

   Li Y, Crompton RH, Gunther MM, Wang W., Savage R (2002). Reconstructing the mechanics of quadrupedalism in an extinct hominoid. Zeitschrift fứr Morphologie und Anthropologie, 83, 265-274.

   Ohman JC, Wood C, Wood B, Crompton RH, Gunther MM, Li Y, Savage R, Wang W. (2002). Stature-at-death of KNM-WT 15000. Human Evolution 17, 129-142.

   Li Y, Wang W., Crompton RH, Gunther MM (2001). Free vertical moments and transverse forces in human walking and their role in relation to arm-swing. Journal of Experimental Biology 204, 47-58.

   Crompton RH, Li Y, Wang W., Gunther MM, Savage R (1998). The mechanical effectiveness of erect and “bent-knee, bent-hip” bipedal walking in Australopithecus Afarensis. Journal of Human Evolution 35, 55-74. Reviewed by Nature (1998, 23 July) Vol. 394, pp. 325.

   Crompton RH, Li Y, Alexander RMcN, Wang W., Gunther MM (1996). Segment inertial properties of primate: new techniques for laboratory and field studies of locomotion. American Journal of Physical Anthropology 99, 547-570.

   Li Y, Crompton RH, Alexander RMcN, Gunther MM, Wang W. (1996). Characteristics of ground reaction forces in normal and chimpanzee-like bipedal walking by human. Folia Primatologica 66, 137-159.

Teaching

Annually invited lectures on Acupuncture and Herbal Medicine for undergraduate medical students in the Queen’s University Belfast (invited by Prof Chris Patterson from Centre for Public Health)

Contribute to the teaching of Master of Public Health programme in Dundee.

He supervises one PhD student (as a co-supervisor) and two MSc students (as a main supervisor) and one MPH student for a dissertation (as a main supervisor) in 2015/2016.

He starts to supervise two MSc students (as a main supervisor) in 2016/2017.

PhD Supervision

Abirami Veluchamy, started 1st December 2015.

Conferences

  • Scottish Pain Research Community (SPaRC) annual scientific meeting. Dundee. Mar 18th, 2016.
  • NADEGS annual conference (GP and NHS education for Scotland). Carnoustie, Scotland. Jan 21st -22nd, 2016.
  • European Society of Human Genetics (ESHG), Glasgow, June 6 - 9th, 2015. 
  • IASP 15th World Congress on Pain, Buenos Aires, Argentina, October 6th -11th, 2014.
  • Speaker: Scottish Pain Research Community (SPaRC) annual scientific meeting, Dundee, March 27th, 2014.

Impact

We have strong links with industries such as Pfizer and GSK.