Dr. Harry L Hébert

Postdoctoral Research Assistant in Genetic Epidemiology

Address:

Division of Population Health Sciences
School of Medicine
Ninewells Hospital & Medical School
Mackenzie Building
University of Dundee
Kirsty Semple Way
Dundee
DD2 4BF

Phone Number:

+(44) 01382 383191

Email Address:

h.hebert@dundee.ac.uk

Biography

Harry is a postdoctoral research assistant with the chronic pain research group and was appointed to his current post in September 2015. Prior to this he graduated from the University of Nottingham in 2009 with a BSc(Hons) in Genetics and then completed an MSc at Imperial College London in Human Molecular Genetics. Having gained an interest for investigating genetic risk factors of complex disorders from the research component of his MSc, he then undertook a PhD at Arthritis Research UK, Centre for Genetics and Genomics at the University of Manchester, studying the genetic basis of late-onset psoriasis under the supervision of Dr Richard Warren, Professor Anne Barton and Dr John Bowes. Following the completion of his PhD at the end 2014, he of took up a short Research Associate position, contributing to a genome-wide association study in psoriatic arthritis and the analysis of age of onset as a quantitative trait in psoriasis.

Harry is currently working with Professor Blair Smith, Professor Colin Palmer and Dr Weihua Meng, to develop a risk model for the development of (severe) neuropathic pain. 

Research

Harry is currently working on DOLORisk, which aims to understand the risk factors and determinants for neuropathic pain. Around 8% of the population live with neuropathic pain, with varying degrees of severity, response to treatment and poor quality of life. The risk factors that contribute to neuropathic pain onset are currently unknown, but involve a combination of heritable and environmental components. Therefore, discovering these risk factors will benefit patients by identifying people at increased risk of developing neuropathic pain, informing pathways for target by therapeutic intervention and ultimately decreasing the burden of healthcare on the NHS.

The aim of the Dundee arm of DOLORisk is to develop a risk model for the development of (severe) neuropathic pain. This will be carried out using two population cohorts, Genetics of Diabetes Audit Research Tayside Scotland (GoDARTS) and Generation Scotland: The Scottish Family Health Study (GS:SFHS). GoDARTS will be used to analyse the association of genetic and environmental risk factors with the presence, absence and progression of neuropathic pain at three different time points. This will then be used to develop a genetic, environmental and gene-environment interaction model for neuropathic pain which will be tested on GS:SFHS.

http://diabetesgenetics.dundee.ac.uk/

http://generationscotland.org/

http://dolorisk.eu/

 

Publications

  • Hébert HL, Ali FR, Bowes J, Griffiths CE, Barton A, Warren RB. Genetic susceptibility to psoriasis and psoriatic arthritis: implications for therapy. British Journal of Dermatology 2012; 166(3):474-82.
  • Hébert HL, Bowes J, Smith RL, McHugh NJ, Barker JN, Griffiths CE, Barton A, Warren RB. Polymorphisms in IL-1B distinguish between psoriasis of early and late onset. Journal of Investigative Dermatology 2014; 134(5):1459-62.
  • Hébert HL, Bowes J, Smith RL, Flynn E, Parslew R, Alsharqi A, McHugh NJ, Barker JN, Griffiths CE, Barton A, Warren RB. Identification of loci associated with late-onset psoriasis using dense genotyping of immune-related regions. British Journal of Dermatology 2015; 172(4):933-9.
  • Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hébert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A. Nature Communications 2015, 6:6046. 
  • Smith RL, Hébert HL, Massey J, Bowes J, Marzo-Ortega H, Ho P, McHugh NJ, Worthington J, Barton A, Griffiths CE, Warren RB. Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis. Archives of Dermatological Research 2016; 308(3): 201-5.   
  • Chang C, Zhang K, Veluchamy A, Hébert HL, Looker HC, Colhoun HM, Palmer CN, Meng W. A genome-wide association study provides new evidence that CACNA1C gene is associated with diabetic cataract. Investigative Ophthalmology and Visual Science 2016; 57(4):2246-50.
  • Hébert HL, Veluchamy A, Torrance N, Smith BH. Risk factors for neuropathic pain in diabetes mellitus. PAIN 2017; 158(4):560-8.  

Conferences

  • Hébert HL, Veluchamy A, Meng W, Palmer CN, Smith BH. DOLORisk Dundee – Development of a risk model for (severe) neuropathic pain [oral presentation]. Scottish Pain Research Community (SPaRC) Annual Scientific Meeting, Dundee, March 2017.    
  • Hébert HL, Bowes J, Smith RL, Parslew R, Alsharqi A, Flynn E, McHugh NJ, Barker JN, Griffiths CE, Barton A, Warren RB. Dense genotyping and human leukocyte antigen imputation identifies two novel loci in late-onset psoriasis [oral presentation]. British Society of Investigative Dermatology Annual Meeting, Newcastle upon Tyne, April 2014.
  • Hébert HL, Bowes J, Flynn E, McHugh NJ, Barker JN, Griffiths CE, Barton A, Warren RB. Characterisation of early-onset psoriasis loci in late-onset psoriasis [poster presentation]. International Investigative Dermatology Meeting, Edinburgh, May 2013.
  • Hébert HL, Bowes J, Smith RL, McHugh NJ, Barker JN, Griffiths CE, Barton A, Warren RB. Polymorphisms in interleukin-1β distinguish between early and late-onset psoriasis [poster presentation]. International Investigative Dermatology Meeting, Edinburgh, May 2013.