Dr. Charis A Marwick

Clinical Senior Lecturer/Honorary Consultant

Clostridium difficile infection, antimicrobial use and resistance: epidemiology and improvement research

Address:

Population Health Sciences,
School of Medicine,
Mackenzie Building,
Kirsty Semple Way
DD2 4BF

Phone Number:

+(44) 01382 383800

Email Address:

c.z.marwick@dundee.ac.uk

Biography

Dr Charis Marwick is a Clinical Senior Lecturer in Population Health Sciences, Consultant in Infectious Diseases and General Medicine in NHS Tayside and Clinical Lead for the Scottish infection Intelligence Platform at NHS National Services Scotland (NSS).

She completed her PhD, through a CSO Clinical Academic Fellowship, at the University of Dundee in 2011 and completed clinical training in June 2012. Her undergraduate degrees, MBChB July 2001 and BScMedSci 1st Class honours July 1999, were from the University of Glasgow.

Her research into the epidemiology of infections, particularly Clostridium difficile infection (CDI), antimicrobial use and antimicrobial resistance (AMR) generates and evaluates evidence to support changes in policy and practice, and evaluates the impact of changes in policy, often involving the use of health informatics. Her multidisciplinary research, including national collaborations through the Scottish Infection Research Network and the Scottish Healthcare Associated Infection Prevention Institute, includes linking bacterial genomic data to routine healthcare data to investigate CDI and AMR. She is a member of the Scottish Antimicrobial Prescribing Group representing IIP and research and chairs the 2016 Scottish CDI Guidance Development Group.

Research

Current research grants:

  • Marwick CA, Chalmers JD, Donnan PT, Nathwani D. The impact of antimicrobial exposure on subsequent antimicrobial resistance in patients with COPD and bronchiectasis. Chief Scientist Office. £225K

  • Marwick C, Douce G, Coia J, Brown D, Quince C, Donnan P, Lindstrom J, Bennie M, Wiuff C, Davey P. Molecular epidemiology of Clostridium difficile in Scotland: developing novel, clinically applicable research methods to combine genomic analysis with health informatics. Scottish Infection Research Network/Chief Scientist Office. £366,638

  • Leonard A, Aanensen D, Bennie M, Coia J, Currie K, Evans T, Gillespie S, Holden M, Knussen C, Lang S, Marwick C, McCowan C, Morris K, Parcell B, Parkhill J, Phillips G, Price L, Reilly J, Robertson C, Walsh T. Scottish Healthcare Associated Infection Prevention Institute (SHAIPI). SIRN Consortium  £4,249,749

  • Leanord A, McCowan C, Walker A, Ford I, Robertson C, Kavanagh K, Bennie M, Marwick C. Clinical and economic outcomes of C. difficile infection in Scotland. Astellas Pharma Ltd £180,237

  • Guthrie B, Marwick C, Davey P, Clarkson J. Health Foundation PhD Awards for Improvement Science. £278,782

  • Davey P, Marwick C, Charani E, Gould I, Ramsay C. Systematic review and meta-analysis of interventions to improve antibiotic prescribing practices for hospital inpatients. Chief Scientist Office. £174,906

  • Hernandez Santiago V, Marwick CA, Davey PG, Guthrie B. A multilevel analysis of the impact of changes in antimicrobial prescribing on antimicrobial resistance. Chief Scientist Office, Clinical Academic Training Fellowship for Dr Hernandez Santiago. £215,658

Publications

Teaching

  • Undergraduate clinical teaching in Infectious Diseases during 4th year ID block

  • Supervision of student projects in infection

  • Medical school examinations

  • Clinical academic mentoring

  • Thesis Monitoring Committee for PhD students

  • Supervising, marking and moderating Masters dissertations

PhD Supervision

Andrea Patton, Evaluating effects of antimicrobial stewardship interventions, 2017

Virginia Hernandez Santiago, A multilevel analysis of the impact of changes in antimicrobial prescribing on antimicrobial resistance, 2017

Sean MacBride-Steward, Measuring and improving primary care prescribing quality and safety using routine data, 2017

 

Conferences

Multidisciplinary and health informatics approaches to tackling AMR.

Learned Society Partnership on Antimicrobial Resistance Networking workshop for researchers; Antimicrobial resistance: environments, evolution and transmission, College of Life Sciences, University of Dundee, 3rd July 2015

Infection Intelligence Platform (IIP): using big data to define infection outcomes.

RCPE Symposium: Emerging and re-emerging infectious diseases, Royal College of Physicians of Edinburgh, 12th June 2015

Evidence for the use of new and old agents for Staphylococcus aureus infections.

Federation of Infection Societies (FIS) annual scientific meeting, Birmingham, 13th November 2013

 

 

Impact

The paper Bell S, Davey P, Nathwani D, Marwick C, Vadiveloo T, Sneddon J, Patton A, Bennie M, Fleming S, Donnan PT. Risk of AKI with Gentamicin as Surgical Prophylaxis. Journal of the American Society of Nephrology 2014:25, led to a change in the national orthopaedic antibiotic prophylaxis policy