Dr. Andrew J Cassidy

Director of the Tayside Centre for Genomic Analysis

Address:

Dr Andrew Cassidy
The Tayside Centre for Genomic Analysis
University of Dundee
School of Medicine, Level 6
Ninewells Hospital and Medical School
DD1 9SY

Phone Number:

+(44) 01382 383268

Email Address:

a.j.cassidy@dundee.ac.uk

Biography

Andrew James Cassidy completed his first Degree at the University of Abertay, later moving to the University of Dundee to complete an MSc in Molecular Biology followed by a PhD in Molecular Genetics. While carrying out this research work he initiated and developed the University’s first DNA Sequencing Facility. Now Director of the Tayside Centre for Genomic Analysis he continues to develop and expand the range of services on offer to the clinical and academic communities in and beyond Dundee.

Research

As Director of the TCGA my research interests are as wide and varied as my colleagues who use the facility. My most recent area of research is in the field of male infertility with Professor Chris Barratt where we took a Whole Exome Sequencing approach to looking at sequence variation in a local cohort of patients.

Prior to that, my research work was in the field of human epithelial genetics with Professor Irwin McLean looking at Molecular Genetics and Structure-Function Analysis in Human Epithelial Disorders. Within this project I identified the gene responsible for Acral Peeling Skin Syndrome as well as being actively involved in looking for the causative genes in a variety of epithelial disorders that alter the structure, function or differentiation of epithelial tissues. Additionally, in collaboration with the Centre for Molecular Medicine in Singapore, I constructed an online database of human intermediate filament variants. The database is accessible via the Internet at http://www.interfil.org and provides a fully searchable relational database of variant information. In November 2007 I completed my PhD and continue to collaborate with Professor McLean on this subject. As Director of the Tayside Centre for Genomic Analysis (TCGA) I continue to support a variety of research projects across the University.

Publications

 

1.       Clarke DJ, Cassidy AJ, See CG et al. Cloning of the human UGT1 gene complex in yeast artificial chromosomes: novel aspects of gene structure and subchromosomal mapping to 2q37. Biochem Soc Trans 1997; 25: S562.

2.       Clarke DJ, Moghrabi N, Monaghan G, Cassidy A, Boxer M, Hume R, Burchell B. Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias. Clin Chim Acta 1997; 266: 63-74.

3.       Jedlitschky G, Cassidy AJ, Sales M et al. Cloning and characterization of a novel human olfactory UDP- glucuronosyltransferase. Biochem J 1999; 340: 837-43.

4.       Monaghan G, McLellan A, McGeehan A, Li Volti S, Mollica F, Salemi I, Din Z, Cassidy A, Hume R, Burchell B. Gilbert’s syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn. J Pediatr 1999; 134: 441-6.

5.       Burchell B1, Soars M, Monaghan G, Cassidy A, Smith D, Ethell B. Drug-mediated toxicity caused by genetic deficiency of UDP- glucuronosyltransferases. Toxicol Lett 2000; 112-113: 333-40.

6.       Cassidy AJ, van Steensel MA, Steijlen PM et al. A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am J Hum Genet 2005; 77: 909-17.

7.       McLean WH, Smith FJ, Cassidy AJ. Insights into genotype-phenotype correlation in pachyonychia congenita from the human intermediate filament mutation database. J Investig Dermatol Symp Proc 2005; 10: 31-6.

8.       Smith FJ, Liao H, Cassidy AJ et al. The genetic basis of pachyonychia congenita. J Investig Dermatol Symp Proc 2005; 10: 21-30.

9.       Sandilands A, O’Regan GM, Liao H, Zhao Y, Terron-Kwiatkowski A, Watson RM, Cassidy AJ, Goudie DR, Smith FJ, McLean WH, Irvine AD. Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis. The Journal of investigative dermatology 2006; 126: 1770-5.

10.    Godfrey V, Chan SL, Cassidy A et al. The Functional Consequence of the Glu298Asp Polymorphism of the Endothelial Nitric Oxide Synthase Gene in Young Healthy Volunteers. Cardiovascular drug reviews 2007; 25: 280-8.

11.    Szeverenyi I, Cassidy AJ, Chung CW et al. The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases. Hum Mutat 2007.

12.    F. E. Paulin, M. O’Neill, G. McGregor, A. Cassidy, A. Ashfield, C. W. Ali, A. J. Munro, L. Baker, C. A. Purdie, D. P. Lane and A. M. Thompson (2008). “MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism.” BMC Cancer 8(1): 281.

13.    Treharne KJ, Cassidy D, Goddard C, Colledge WH, Cassidy A, Mehta A (2009) Epithelial IgG and its relationship to the loss of F508 in the common mutant form of the cystic fibrosis transmembrane conductance regulator. FEBS Lett.

14.    Oparka R, Cassidy A, Reilly S, Stenhouse A, McCluggage WG, Herrington CS (2012) The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour. Histopathology.

15.    Kluk MJ1, Ashworth T, Wang H, Knoechel B, Mason EF, Morgan EA, Dorfman D, Pinkus G, Weigert O, Hornick JL, Chirieac LR, Hirsch M, Oh DJ, South AP, Leigh IM, Pourreyron C, Cassidy AJ, Deangelo DJ, Weinstock DM, Krop IE, Dillon D, Brock JE, Lazar AJ, Peto M, Cho RJ, Stoeck A, Haines BB, Sathayanrayanan S, Rodig S, Aster JC. Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One. 2013;8(6):e67306.

16.    van der Velden JJ1, van Geel M, Nellen RG, Jonkman MF, McGrath JA, Nanda A, Sprecher E, van Steensel MA, McLean WH, Cassidy AJ. Novel TGM5 mutations in acral peeling skin syndrome. Exp Dermatol. 2015;24(4):285-9.

17.    Gormley K, Mackenzie C, Robins P, CosciaI, Cassidy A, James J, et al. (2015) Connectivity and Dispersal Patterns of Protected Biogenic Reefs:Implications for the Conservation ofModiolusmodiolus (L.) in the Irish Sea. PLoS ONE 10(12): e0143337. doi: 10.1371/journal.pone. 0143337

Teaching

BMSc Genetics

Supervisor MSc HCEAC

Conferences

  • 2012 American Society of Human Genetics, “Can genetic variation of CES1A predict methylphenidate response in ADHD Patients?”
  • 2015 University of Dundee Symposium, talk entitled “The Tayside Centre for Genomic Analysis”
  • 2015 University of Dundee (SLS), Eastbio Word Class Bioscience: Novel Techniques Meeting
  • 2016 A Career in Science, Dundee and Angus College

Impact

Honorary Clinical Scientist with NHS Tayside (2008 – Present)

Associate Member of Staff with the Division of Molecular Medicine.

2016. Presentation to Dundee and Angus College, “A Career in Science.”