Yogesh studied Chemical Engineering as an undergraduate. An elective course on recombinant DNA technology sparked his interest in molecular biology. He then went on to do a PhD in Immunology at the Max Planck Institute of Immunobiology in Germany. Yogesh did his postdoctoral training at the MRC Laboratory of Molecular Biology, Cambridge where he learnt to apply structural biology methods to study cell signalling. In 2013, Yogesh relocated to Dundee to establish his research program, focussing on ubiquitin signalling mechanisms. He was selected to the EMBO Young Investigator Programme in 2015 and was awarded a Lister Research Prize in 2017.
Ubiquitylation is a versatile posttranslational modification (PTM) that drives virtually every cellular process. An important role of ubiquitylation is in the quality control and degradation of misfolded and damaged proteins, a process central to maintaining a functional proteome or proteostasis. Failure to degrade proteins in a timely manner is the underlying cause of many neurodegenerative diseases that afflict millions of people worldwide. Hence, studying how ubiquitylation regulates protein degradation to maintain protein homeostasis is important to not only understand the molecular causes of disease but also for the development of effective therapeutic strategies, and forms the main research goal of my lab. I will present recent exciting results about a family of deubiquitinating enzymes that are hitherto unstudied important regulators of protein degradation and proteostasis.