The lecture will illustrate how designer small molecules can help elucidate cellular processes in a way that is complementary to molecular biology. It will focus particularly on our work on mitochondria, but will touch on other areas, drawing on examples of: the exomarker approach for quantifying mitochondrial reactive species such as ROS in whole organisms; small molecule modulators to affect cellular processes in particular those involved in redox regulation and cancer; and photoactivatable compounds that allow complete spatial and temporal control of signalling or energy supply.
Prof. Richard Hartley received a PhD in chemistry from the University of Cambridge (1991). After post-doctoral work at McGill University, Montreal, he joined University College Dublin, and then moved to the University of Glasgow (1995). He is now Professor of Chemical Biology. Prof. Hartley develops small molecular probes for elucidating biological processes both on a cellular and a whole organism level. His current work focuses on mitochondria and redox signaling. His particular successes have been the development of probes to produce exomarkers, potential therapeutics for diseases involving mitochondrial dysregulation, and photoactivatable probes that allow control of mitochondrial activity.