Grand Rounds - Making a Difference: Impact of Research from the School of Medicine

Speaker: 
Professor Chim Lang
Institution: 
University of Dundee
Date: 
Thursday, 3 May, 2018 - 13:00
Location: 
Gannochy Trust Lecture Theatre, Level 7, Ninewells

REPURPOSING DRUGS FOR CARDIOVASCULAR DISEASES

Professor CC Lang

Division of Molecular & Clinical Medicine, Ninewells Hospital, University of Dundee, DD1 9SY

Despite the tremendous resources invested in cardiovascular (CV) drugs, CV diseases remain the major cause of deaths and hospitalization worldwide. Drug development is an expensive and time-consuming process with a success approval rate of only less than 5%. This emphasizes the need for an alternative drug development strategy. “Repurposing” existing drugs is one such alternative that is currently being explored. In this presentation, we wish to share our program of research that has helped change clinical practice guidelines to recommend the use of previously contraindicated drugs  to improve outcomes in patients with cardiovascular diseases. Investigating the use of renin angiotensin system (RAS) blockers, our research has shown that these classes of drugs can be used to treat hypertension in patients with aortic stenosis and to alleviate symptoms in patients with aortic regurgitation. Our research has shown the safe and important use of metformin in patients with diabetes mellitus and heart failure. The global impact of our research is reflected in international clinical practice guidelines and statements

References

  1. Nadir MA, Wei L, Elder DH, et al. Impact of renin-angiotensin system blockade therapy on outcome in aortic stenosis. J Am Coll Cardiol. 2011;58:570-6 . Impact factor 19.896. SCOPUS CITATION=74
  2.  Elder DH, Wei L, Szwejkowski BR, et al. The impact of renin-angiotensin-aldosterone system blockade on heart failure outcomes and mortality in patients identified to have aortic regurgitation: a large population cohort study. J Am Coll Cardiol. 2011;58:2084-9 . Impact factor 19.896. SCOPUS CITATION=23
  3. Evans JM, Doney AS, Alzadjali MA, Ogston SA, Petrie JR, Morris AD, Struthers AD, Wong AK, Lang CC. Effect of Metformin on Mortality in Patients With Heart Failure and Type 2 Diabetes Mellitus. Am J Cardiol. 2010 Oct 1;106(7):1006-1010. IMPACT FACTOR: 3.154. SCOPUS CITATION=41
  4. Cameron AR, Morrison VL, Levin D, Mohan M, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016 Aug 19; 119(5): 652-65. IMPACT FACTOR: 13.965. SCOPUS CITATION: 33
  5. Rena G, Lang CC. Repurposing metformin for cardiovascular disease. Circulation 2018: Jan 30;137(5):422-424. IMPACT FACTOR 19.309

 

Department: 
CMDN
School of Medicine
Medical Research Institute