Keith Caldecott conducted his PhD in DNA repair the laboratory of Penny Jeggo at the MRC National Institute for Medical Research in London. Keith's interest in DNA repair continued during postdoctoral fellowships with Larry Thompson (California) and Tomas Lindahl FRS (London), and in 1995 he established his own laboratory at the University of Manchester. In 2002, Keith moved his lab to the MRC Genome Damage and Stability Centre (GDSC) at the University of Sussex, where he is now Professor and Deputy Director.
Chromosomal DNA strand breaks are the commonest and most cytotoxic lesions arising in mammalian cells and their repair is critical for genetic integrity, cell survival, and for normal embryonic development. Loss of DNA strand break repair in humans results in a range of pathologies including developmental and progressive neurological dysfunction, immunodeficiency, and predisposition to cancer. My laboratory is focused on identifying and characterising novel human proteins involved in DNA strand break repair processes and understanding how these processes are coordinated at the molecular level. We are also examining how defects in DNA strand break repair result in disease pathology, with particular emphasis on neurological disease.