Development of high Z nanoparticle platforms for theranostic applications in radiotherapy

Dr Karl Butterworth (Queens University Belfast)
Thursday, 9 March, 2017 - 12:00
Tanis Drummond Lecture Theatre, Level 5, Ninewells Hospital & Medical School


Over the past two decades, there has been a significant evolution in the technologies and techniques employed in radiation oncology. Over the same period, extensive research into the use of nanotechnology in medicine has highlighted a range of potential benefits to its incorporation into radiotherapy. In this context, high atomic number (Z) nanoparticles have been proposed as novel theranostic agents, capable of improving both imaging and radiation response due to their strong photoelectric absorption coefficient. Using a range of different biological systems, from plasmid DNA to small animal models, we are evaluating the dose modifying properties of different gold and gadolinium based nanoparticle platforms. Whilst these studies provide evidence for the use of these agents in combination with radiotherapy, there remains a number of barriers to clinical translation. A review of our experimental findings will be presented focussing on the evidence supporting underlying radiobiological response mechanisms and potential applications for MRI guided adaptive radiotherapy.

Everyone is welcome.

Refreshments will be provided.

School of Medicine
Medical Research Institute
Division of Cancer Research