Applications are invited for a Postdoctoral researcher to study the regulation of chromosome segregation in the laboratory of Dr Adrian Saurin at the Jacqui Wood Cancer Centre, University of Dundee. This is a CRUK-funded position that is available for 3 years in the first instance.
Kinases and phosphatases orchestrate a vast array of intracellular responses by toggling phosphorylation sites on and off. Although these enzymes work antagonistically on individual molecules, they also work together to define how these molecules behave collectively in time and space. This “cooperativity” is something we know almost nothing about and yet it can determine critical features of a signalling response (1,2). For example, we showed recently how the mitotic checkpoint integrates the activities of two kinases and two phosphatases to generate a localised signal that can turn on and off rapidly (3). This postdoctoral position is to examine the importance of kinase-phosphatase coupling in chromosome segregation, and in particular, how dynamic phosphorylation events can underlie important signalling behaviours (2).
For further information about this position please refer to the job description or contact Dr Adrian Saurin at email@example.com. To find out more about the lab please visit www.SaurinLab.com.
(1) Gelens L, Qian J, Bollen M and Saurin AT. The Importance of Kinase-Phosphatase Integration: Lessons from Mitosis. Trends in Cell Biology. 2017.
The successful applicant will
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